Shimizu A, Ishiko A, Ota T, Tsunoda K, Koyasu S, Masayuki A, Nishikawa T. Ultrastructural change in miceq actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris. Arch Dermatol Res 249 (7): pp.318-323 2002. 11.
Cheng X, Mihindukulasuriya K, Den Z, Kowalczyk AP, Calkins CC, Ishiko A, Shimizu A, Koch PJ. Assessment of splice variant-specific functions of desmocollin 1 in the skin. Mol Cell Biol 24(1): pp.154-63. 2004. 1.
Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M, Nishikawa T. IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model. J Invest Dermatol 122(5): pp.1145-1153 2004. 5.
Ishiko A, Shimizu A, Nagata E, Ohta K, Tanaka M. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephaloapthy (CADASIL): A Hereditary Cerebrovascular Disease, Which Can Be Diagnosed by Skin Biopsy Electron Microscopy. Am J Dermatopathol 27(2): pp.131-134. 2005. 4.
Shimizu A, Ishiko A, Ota T, Saito H, Oka H, Tsunoda K, Amagai M, Nishikawa T. In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line. J Invest Dermatol. 124(5): pp.984-989 2005. 5.
Shimizu A, Akiyama M, Ishiko A, Yoshiike T, Suzumori K, Shimizu H. Prenatal exclusion of harlequin ichthyosis; potential pitfalls in the timing of the fetal skin biopsy. British Journal of Dermatology:153(4): pp.811-814 2005. 10.
Ishiko A, Shimizu A, Nagata E, Takahashi K, Tabira T, Suzuki N. Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL. Acta Neuropathol (Berl);112(3):pp.333-339 2006. 7.
Oki K, Nagata E, Ishiko A, Shimizu A, Tanaka K, Takahashi K, Tabira T, Katayama T, Suzuki N. Novel mutation of the Notch3 gene in a Japanese patient with CADASIL. Eur J Neurol. 14(4): pp464-6 2007. 4
Yabuzoe A, Nishifuji K, Sekiguchi M, Shimizu A, Momoi Y, Ishiko A, Iwasaki T. Neutrophils contact to plasma membrane of keratinocytes including desmosomal structures in canine pemphigus foliaceus. J Vet Med Sci. 70(8): pp807-812. 2008. 8
Yabuzoe A, Shimizu A, Nishifuji K, Momoi Y, Ishiko A, Iwasaki T.Canine pemphigus foliaceus antigen is localized within desmosomes of keratinocyte. Vet Immunol Immunopathol. 127(1-2): pp57-64. 2009. 1
Baba T, Shimizu A, Ohmuro T, Uchida N, Shibata K, Nagata M, Shirota K. Auricular chondritis associated with systemic joint and cartilage inflammation in a cat. J Vet Med Sci. 71(1): pp79-82. 2009. 1
Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 106(23): pp9292-9297. 2009. 6
Saito H, Shimizu A, Tsunoda K, Amagai M, Ishiko A. Subcellular localization of desmosomal components is different between desmoglein3 knockout mice and pemphigus vulgaris model mice. J Dermatol Sci. 55(2): pp108-115. 2009. 8
Kobayashi T, Shimizu A, Nishifuji K, Amagai M, Iwasaki T, Ohyama M. Canine hair-follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells. Vet Dermatol. 20(5-6): pp338-346. 2009. 10
Ohyama M, Shimizu A, Tanaka K, Amagai M. Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata. J Dermatol Sci. 58(2): pp154-157. 2010. 5
Nishifuji K, Shimizu A, Ishiko A, Iwasaki T, Amagai M. Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation. J Dermatol Sci. 59(3): pp184-191. 2010. 9
Kouno M, Ko R, Shimizu A, Ouchi T, Sueoka K, Masunaga T, Ishiko A. A Japanese-specific recurrent mutation and a novel splice site mutation in the LAMC2 gene identified in two Japanese families with Herlitz junctional epidermolysis bullosa. Clin Exp Dermatol. 36(4): pp386-392. 2011. 1
Tsunoda K, Ota T, Saito M, Hata T, Shimizu A, Ishiko A, Yamada T, Nakagawa T, Kowalczyk AP, Amagai M. Pathogenic Relevance of IgG and IgM Antibodies against Desmoglein 3 in Blister Formation in Pemphigus Vulgaris. Am J Pathol. 179(2): pp795-806. 2011.
Hirose M, Recke A, Beckmann T, Shimizu A, Ishiko A, Bieber K, Westermann J, Zillikens D, Schmidt E, Ludwig RJ. Repetitive Immunization Breaks Tolerance to Type XVII Collagen and Leads to Bullous Pemphigoid in Mice. J Immunol. 187(3): pp1176-1183. 2011.
Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M. Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol. 129(6): pp1538-1546.e6. 2012
Ohyama M, Kobayashi T, Sasaki T, Shimizu A, Amagai M.
Restoration of the intrinsic properties of human dermal papilla in vitro. J Cell Sci. 125(17): pp4114-4125. 2012.
Shimizu A, Funakoshi T, Ishibashi M, Yoshida T, Koga H, Hashimoto T, Amagai M, Ishiko A. IgG deposition to non-hemidesmosomal lamina lucida and the early neutrophil involvement are the characteristic features in a case with anti-p200 pemphigoid. Br J Dermatol. 168(3): pp647-655. 2013. 3
Iwata H, Bieber K, Tiburzy B, Chrobok N, Kalies K, Shimizu A, Leineweber S, Ishiko A, Vorobyev A, Zillikens D, Köhl J, Westermann J, Seeger K, Manz R, Ludwig RJ. B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita. J Immunol. 191(6): pp2978-2988. 2013. 8
Kumagai Y, Umegaki-Arao N, Sasaki T, Nakamura Y, Takahashi H, Ashida A, Tsunemi Y, Kawashima M, Shimizu A, Ishiko A, Nakamura K, Tsuchihashi H, Amagai M, Kubo A. Distinct phenotype of epidermolysis bullosa simplex with infantile migratory circinate erythema due to frameshift mutations in the V2 domain of KRT5. J Eur Acad Dermatol Venereol. 31(5): pp e241-e243. 2016. 2
Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. J Dermatol Sci. 85(3): pp197-207. 2017. 12
Heppe EN, Tofern S, Schulze FS, Ishiko A, Shimizu A, Sina C, Zillikens D, Köhl J, Goletz S, Schmidt E. Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease. J Invest Dermatol. 137(8): pp1709-1718. 2017. 4
Ueda K, Kawai T, Senno H, Shimizu A, Ishiko A, Nagata M. Histopathological and electron microscopic study in dogs with patellar luxation and skin hyperextensibility. J Vet Med Sci. 2018.
Shimizu A, Ishiko A, Ota T, Tsunoda K, Koyasu S, Amagai M, Nishikawa T
Characterization of mouse pemphigus vulgaris model using immunoelectron microscopy
The 62nd Annual Meeting of the Society for Investigative Dermatology, Washington DC, 2001. 05.
Ishiko A, Shimizu A, Tsunoda K, Koyasu S, Amagai M, Nishikawa T.
Immunoelectron microscopic analysis of pemphigus vulgaris mouse model.
4th Joint Meeting of The Society for Cutaneous Ultrastructure Research and The Japanese Society for Ultrastructural Cutaneous Biology, Limoges, France, 2002. 06.
Shimizu A, Ishiko A, Tsunoda K, Koyasu S, Amagai M, Nishikawa T.
A phathogenic anti-DSG3 monoclonal antibody binds along the dense mid-line of desnosome.
4th Joint Meeting of The Society for Cutaneous Ultrastructure Research and The Japanese Society for Ultrastructural Cutaneous Biology, Limoges, France, 2002. 06.
Ishiko A, Yoshida R, Shimizu A, Amagai M, Nishikawa T.
Generalized argyria due to “JINTAN” silver pills for breath freshener.
20th World Congress of Dermatology, Paris, France, 2002. 07.
Saito H, Ishiko A, Shimizu A, Tanaka M, Nishikawa T.
An immunoelectron microscopic analysis of a case of pemphigus vulgaris.
The 7th China-Japan Joint Meeting of Dermatology, Guangzhou, China, 2002. 12.
Shimizu A, Ishiko A, Ota T, Tsunoda K, Amagai M and Nishikawa T.
Cleavage of desmosomes occurs without keratin retraction in vivo in pemphigus vulgaris model mice.
International Investigative Dermatology 2003, Miami Beach, Florida USA, 2003. 04.
Shimizu A, Ishiko A, Nishikawa T, Cheng X, Mihindukulasuriya K, Koch PJ.
Ultrastructural assessment of the splice variant-specific function of Dsc1 in the epidermis.
31th Annual Meeting The Society for Cutaneous Ultrastructure Research Joint Meeting with the European Society of Dermatopathology, Roma, Italia, 2004. 5.
Hitoshi S, Ishiko A, Shimizu A, Nishikawa T.
The ultrastructural localization of desmosomal components in desmoglein3 knockout mouse.
31th Annual Meeting The Society for Cutaneous Ultrastructure Research Joint Meeting with the European Society of Dermatopathology, Roma, Italia, 2004. 5.
Ishiko A, Shimizu A, Nagata E, Ohta K, Tanaka M.
Two cases of CADASIL (cerebral autosomal dominant arteriopathy with subcortical infracts and leukoencephaloapthy) diagnosed by skin biopsy electron microscopy.
31th Annual Meeting The Society for Cutaneous Ultrastructure Research Joint Meeting with the European Society of Dermatopathology, Roma, Italia, 2004. 5.
Shimizu A, Ishiko A, Murayama N, Magata M.
Black hair follicular dysplasia in a dog; an ultrastructural study using transmission electron microscopy.
5th World Congress of Veterinary Dermatology. Vienna, Austria, 2004. 8.
Sakurai K, Sekiguchi M, Momoi A, Shimizu A, Ishiko A, Iwasaki T.
Nonlethal junctional epidermolysis bullosa in a dog.
5th World Congress of Veterinary Dermatology. Vienna, Austria, 2004. 8.
Yabuzoe A, Nishihuji K, Shimizu A, Momoi Y, Ishiko A and Iwasaki T
Ultrastructural localozation of binding site of serum antibodies in pemphigus foliaceus by post-embedding immunoelectron microscopy in one dog.
North American Veterinaly Dermatology Forum 2006, Palm Springs, CA, 2006, 4.
Shimizu A, Ishibashi M, Yoshida M, Amagai M and Ishiko A.
IgG in a patient with anti-p200 pemphigoid restricted to the non-hemidesmosomal area of lower lamina lucida.
33th Annual Meeting The Society for Cutaneous Ultrastructure Research, Warsaw, Poland, 2006. 6.
Shimizu A, Tanaka K, Amagai M and Ohyama M.
Ebastin, a second-generation antihistamin, as a supportive medication for alopecia areata.
Fifth International Congress of Hair Research, Vancourver, Canada, 2007, 6.
Kobayashi T, Shimizu A, Amagai M, Iwasaki T and Ohyama M.
Identification of human bulge cell counterpart in canine hair follicles: A valuable materials for stem cell investigation.
International Investigative Dermatology 2008, Kyoto, Japan, 2008. 05.
Ohyama M, Shimizu A, Kobayashi T and Amagai M.
Microarray analysis of freshly-microdissectd intact human dermal papilla identified upregulation of genes that could contribution to biological distinctiveness.
International Investigative Dermatology 2008, Kyoto, Japan, 2008. 05.
Tsunoda K, , Ota T, Hata T, Shimizu A, Yamada T, Nakagawa T and Amagai M.
IgM to IgG isotype switching of anti-desmoglein3 antibodies is an essential step for pathogenesis of pemphigus vlugaris.
International Investigative Dermatology 2008, Kyoto, Japan, 2008. 05.
Shimizu A, Ishiko A and Nagata M
Morphological findings of the hair in Russian blue were indistinguishable from those of CDA in dogs.
6th World Congress of Veterinary Dermatology. Hong Kong China, 2008. 11.
Kobayashi T, Shimizu A, Nishihuji K, Amagai M, Iwasaki T and Ohyama M.
Identification and Isolation of highly proliferative canine hair follicle bulge cells, promising candidates for stem cells.
6th World Congress of Veterinary Dermatology. Hong Kong China, , 2008. 11.
Yabuzoe ANishifuji K, Shimizu A, Ishiko A, Iwasaki T.
Canine pemphigus foliaceus (PF) autoantigen co-localize with desmoglein 1 in canine keratinocytes.
6th World Congress of Veterinary Dermatology. Hong Kong China, 2008. 11.
Baba T, Shimizu A, Ohmuro T, Uchida N, Shibata K, Nagata M, Shirota K.
A feline case of auricular chondritis with systemic involvements of the joints and
cartilage tissue
6th World Congress of Veterinary Dermatology. Hong Kong China, 2008. 11.
Ohyama M, Kobayashi T, Shimizu A, Amagai M.
Activation of WNT and BMP signaling pathways and forced cell aggregation enabled the generation of human dermal papilla equivalent with trichogenic activity.
Annual Meeting of the Society for Investigative Dermatology, Montreal, Quebec, Canada, 2009. 06.
Shimizu A, Ikoma S, Nagata M, Murayama N, Shimura Y, Ishiko A.
A case of Ehlers-Danlos syndrome in Japanese monkey.7th
World Congress of Veterinary Dermatology. Vancouver, Canada, 2012. 07.
Iwata H, Bieber K, Leinweber S, Tiburzy B, Shimizu A, Ishiko A, Schmidt E, Manz R, Zillikens D, Seeger K, Ludwig RJ. CD4+ T cells control loss of self-tolerance in experimental epidermolysis bullosa acquisita. 42nd Annual ESDR Meeting, Venice, Italy, 2012. 09
Iwata H, Bieber K, Leinweber S, Tiburzy B, Shimizu A, Ishiko A, Schmidt E, Manz R, Zillikens D, Seeger K, Ludwig RJ. Different pathogenecity of IgG subclasses in experimental epidermolysis bullosa acquisita. The 37th Annual Meeting of the Japanese Society for Investigative Dermatology, Okinawa, Japan, 2012. 12.
Iwata H, Bieber K, Tiburzy B, Chrobok N, Kalies K, Shimizu A, Leineweber S, Ishiko A, Schmidt E, Zillikens D, Westermann J, Seeger K, Manz R, Ludwig RJ. CD4, but not CD8, T cells are required for induction of experimental epidermolysis bullosa acquisita. International Investigative Dermatology, Edinburgh, Scotland. 2013, 5.
Yoshida K, Ishii K, Shimizu A, Yokouchi M, Stanley J, Ishiko A. Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering. Annual Meeting of the Society for Investigative Dermatology, New Mexico, USA. 2014, 5.
Shimaoka Y, Shimizu A, Ishiko A, Koike M, Hatamochi A. A case of Ehlers-Danlos syndrome in a Japanese monkey. The 11th meeting of the German-Japan Society of Dermatology. Heidelberg, Germany, 2014, 6.
Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T, Seeger K, Dahlke M, Rades D, Zillikens D, Ludwig RJ. Radiosensitive cells determine clinical disease manifestations in the effector phase of epidermolysis bullosa acquisita. 41st Annual ADF Meeting, 2015, Ulm, Germany, 2015, 3.
Iwata H, Bieber K, Leinweber S, Tiburzy B, Shimizu A, Ishiko A, Schmidt E, Manz R, Zillikens D, Seeger K, Ludwig R. J.
Different pathogenecity of IgG subclasses in experimental epidermolysis bullosa acquisita.
第37回日本研究皮膚科学会，沖縄，2012. 12
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